The wreck happened in the westbound lanes near Exit 71 (PA 33) around 2:35 p.m., said PennDOT on the 511pa website.
The closures were still in effect as of 3:30 p.m.
Click here to follow Daily Voice Upper Dublin and receive free news updates.
All lanes of Interstate 78 are closed in Williams Township after a crash near the New Jersey border, according to transportation officials.
The wreck happened in the westbound lanes near Exit 71 (PA 33) around 2:35 p.m., said PennDOT on the 511pa website.
The closures were still in effect as of 3:30 p.m.
Click here to follow Daily Voice Upper Dublin and receive free news updates.